Plat CLIA Kit for Rat(Rattus norvegicus) | EIAab.comPlat CLIA Kit for Rat(Rattus norvegicus)

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Index > Protein center > Plat(Gene name) > Rat

Plat (Gene name),

Tissue-type plasminogen activator (Protein name ), TPA_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Plat;

Protein name:

Tissue-type plasminogen activator(t-PA;t-plasminogen activator;tPA);

Alternative:

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Heterodimer of chain A and chain B held by a disulfide bond. Binds to fibrin with high affinity. This interaction leads to an increase in the catalytic efficiency of the enzyme due to an increase in affinity for plasminogen. Similarly, binding to heparin increases the activation of plasminogen. Binds to annexin A2, cytokeratin-8, fibronectin and laminin. Binds to mannose receptor and the low-density lipoprotein receptor-related protein (LRP1); these proteins are involved in TPA clearance. Binds LRP1B; binding is followed by internalization and degradation.

Function:

Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events.

Subcellular Location:

Secreted extracellular space

Protein Attributes:

Sequence length:

559

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

559:

NWIQDNMKQ

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

P19637

Pfam:

PF00008

KEGG:

rno:25692

STRING:

10116.ENSRNOP00000025764

UniGene:

Rn.107102

SMR:

P19637

Uniprot:

P19637

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ELISA Kit for Rat t-PA

Cat.:

E0525p

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96T

ELISA Kit for Rat t-PA

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E0525h

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ELISA Kit for Rat t-PA

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E0525r

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ELISA Kit for Rat t-PA

Cat.:

E0525m

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96T

ELISA Kit for Rat t-PA

Cat.:

E0525b

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96T

CLIA Kit for Rat t-PA

Cat.:

U0525m

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96T

CLIA Kit for Rat t-PA

Cat.:

U0525b

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Packing:

96T

CLIA Kit for Rat t-PA

Cat.:

U0525p

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Rat t-PA

Cat.:

U0525h

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MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Rat t-PA

Cat.:

U0525r

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96T

Polyclonal Antibody for Rat t-PA

Cat.:

P0525Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat t-PA

Cat.:

P0525Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat t-PA

Cat.:

P0525Rb-r

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Packing:

40ug/0.2ml

Monoclonal Antibody for Rat t-PA

Protein for Rat t-PA

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Cloning and characterization of a cDNA for rat tissue-type plasminogen activator."
Ny T. , Leonardsson G. , Hsueh A.J.W.
DNA7:671-677(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

"The structure of the TATA-less rat tissue-type plasminogen activator gene. Species-specific sequence divergences in the promoter predict differences in regulation of gene expression."
Feng P. , Ohlsson M. , Ny T.
J. Biol. Chem.265:2022-2027(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Pituitary.

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